The lord [...] is Strefan Maurer, who drank angel's blood alongside Edgar Markov and Olivia Voldaren centuries ago. His bloodline is small and mostly irrelevant to the larger world, but in the outland valleys of Stensia, he is the ultimate master.

In their stately manor houses, sprawling courts, and towering castles, four great family lines of vampires [...]

Innistrad's ancient history speaks of a human alchemist and healer named Edgar Markov, who sought to preserve his own life and the lives of his family. As old age began to claim him, he despaired [...] and turned to black magic. [...] the demon Shilgengar appeared to Markov and revealed a means by which he could achieve immortality: a dark ritual that involved drinking an angel's blood.
The vampires of Innistrad are all descended from twelve ancient sires—the congregation that participated in Markov's blasphemous ritual. Of these twelve bloodlines, four constitute the vast majority of Innistrad's vampires: Markov, Voldaren, Falkenrath, and Stromkirk.

[... Of these twelve bloodlines, four constitute the vast majority of Innistrad's vampires: Markov, Voldaren, Falkenrath, and Stromkirk.] Three of the others have died out completely, while five are so few in number as to be irrelevant. One of those nearly irrelevant lines is that of Strefan Maurer, who rules a remote region in Stensia's outland valleys.

[...] Strefan studied magic and forged a pact with the demon Shilgengar in return for the promise of immortality. After murdering his brother Sergei and drinking his blood, Strefan journeyed to Markov Manor and consulted with Edgar Markov. Together, they worked with Shilgengar to create the twelve bloodlines of vampires on Innistrad. Maurer Estate (Castle Ravenloft) was not spirited away to a demiplane—it was already on Innistrad [...]. And Strefan is not trapped here, so he is not seeking a successor in hopes of escaping.

[...] a line of vampires called the Duskens, named after their longlost progenitor Irska Dusken. Strefan killed Irska centuries ago and scattered the Duskens. Some were subjugated, while others went to live among the Bitterhearts.
Rahadin has been serving the Maurer family for many years, and even helped Strefan subjugate the rest of his line. He appears human rather than elflike, and dresses in red finery rather than wearing black armor.

[...] the infamous twins of Maurer Estate, two young girls named Ruby and Carmine. The two enjoy pretending to be helpless young girls, lost and alone, in order to get close to their prey.

As with every set, the Set Design team puts together a list of the main draft archetypes. Normally, we default to the ten two-color pairs, and LTR doesn't deviate from that. Here's what each color pair is up to:
(Note: I'm going to use "typal" a few times in this section. That's an internal way that we refer to cards that care about creature type.)

White-Blue: This archetype is a midrange deck often using evasion as the win condition with a "draw a second card" theme.

Blue-Black: This archetype is a controlling amass deck. It has a milling aspect, allowing you to mill yourself for gain or the opponent to win. It also has a light Human typal element.

Black-Red: This archetype is an aggressive amass deck. It has a sacrifice component as well as an Orc and Goblin (as a batch) typal element.

Red-Green: This archetype is a ramp "power matters" deck pairing larger red creatures with green Treefolk. It also dips into the wild creature element of the set.

Green-White: This archetype is an aggressive Hobbit deck that makes use of Food tokens.

White-Black: This archetype is a "legendary creatures matter" deck that makes use of the Ring tempts you mechanic. It has more legendary creatures and a sacrifice component. The Ring helps you splash a bit more than other archetypes.

Blue-Red: This archetype leans on a Wizards theme and has an "instants and sorceries matter" center. It's a control archetype that rewards you for casting a lot of spells.

Black-Green: This archetype has a life and death theme. It sacrifices and regrows cards. It's the other archetype that makes major use of Food tokens.

Red-White: This archetype is a go-wide Humans deck. It ranges from aggro to midrange depending on what cards you draft.

Green-Blue: This archetype is a tempo Elf deck. It has some Elf typal elements and rewards for scrying.